Immune checkpoint

Immune checkpoint
: Cytotoxin T cell 수용체(receptor) PD1에 리간드(ligand) PDL1가 결합하여 Cytotoxin T cell을 비활성화 시킨다.

 

Usage

- TMB : tumor mutation burden, 종양 돌연변이 빈도

- ICT : Immune checkpoint therapy

- CD8 : cluter of differentiation 8

- TCR : T-cell receptor

- PD1 : programmed cell death receptor 1

- PDL1 : programmed cell death receptor ligand 1

- CTLA4 : cytotoxic T-lymphocyte-associated antigen 4

- MHC I : major histocompatibility complex class I

  (found on all nucleated cells in the body)

- MHC II : major histocompatibility complex class II

  (only found on what's called antigen presenting cells, B-cell, Macrophages, Dendritic cells) >-(TCR, CD$)-(Helper T-cell)

 

PD1 + PDL1 = deactivate 'Cytotoxic T cell'

 

 

 

 

 

 

 

 

 

Reference

- Tumour immunology and immunotherapy, https://youtu.be/K09xzIQ8zsg

- Immunology in the skin, https://youtu.be/_VhcZTGv0CU

- Decoding cancer immunology: Hunting hidden tumours, https://youtu.be/vponeaNiewE

- IMMUNOTHERAPY: The Path to a Cancer Cure (For Clinicians), https://youtu.be/UbFjiWOBErA